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Editorial Board/Publication information
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CO2
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The genetic bases of cancer
Summary: Two different views are presently offered to explain the cancer epidemiological data. One relies on the assumption that cancer is environmentally caused whereas the other assumes that genetic...
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Roberto Taramelli
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1-2
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NK cell-mediated immune response against cancer
Summary: The past fifteen years have witnessed great progress in our undestanding of how natural killer (NK) cells function, their role in innate defenses and their possibile exploitation in therapy. ...
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Lorenzo Moretta
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3-5
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Molecular heterogeneity of colorectal cancer: Implications for cancer control
Summary: Colorectal cancer (CRC) is a multi-pathway disease. A molecular approach to the classification of CRC utilises: (1) the type of genetic instability, specifically microsatellite instability (M...
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Jeremy R. Jass
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7-9
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Genetic alteration in hereditary colorectal cancer
Summary: Colorectal cancer is a major cause of morbidity and mortality. Both genetic and environmental factors contribute to cancer aetiology. About 15–20% of all colorectal cancers are familial. Appr...
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G. Dionigi,
V. Bianchi,
F. Rovera,
L. Boni,
M. Annoni,
P. Castano,
F. Villa,
R. Dionigi
et al.
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11-15
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Inherited multitumoral syndromes including colorectal carcinoma
Summary: Inherited multitumoral syndromes including colorectal carcinoma are the followings: familial adenomatous polyposis (FAP), hereditary non-polyposis colon cancer (HNPCC) and Peutz–Jeghers syndr...
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F. Cetta,
A. Dhamo
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17-23
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Up-regulation and stabilization of HIF-1α in colorectal carcinomas
Summary: Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates gene expression in critical pathways involved in tumor growth and metastases. In our study we evaluated the express...
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Daniela Furlan,
Nora Sahnane,
Ileana Carnevali,
Roberta Cerutti,
Silvia Uccella,
Valentina Bertolini,
Anna Maria Chiaravalli,
Carlo Capella
et al.
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25-27
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Free circulating DNA as possible tumour marker in colorectal cancer
Summary: Aim of the study: The purpose of this study is to evaluate the sensitivity and specificity of free circulating DNA (CFDNA) as a potential tumour marker in patients suffering from colorectal c...
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L. Boni,
E. Cassinotti,
M. Canziani,
G. Dionigi,
F. Rovera,
R. Dionigi
et al.
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29-31
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Experimental therapeutic approaches to adenocarcinoma: The potential of tumor cells engineered to express MHC class II molecules combined with naked DNA interleukin-12 gene transfer
Summary: We have previously shown that TS/A murine mammary adenocarcinoma cells, induced to express high surface expression of MHC class II molecules by stable transfection of CIITA, resulted in high ...
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Lorenzo Mortara,
Luca Giuliani,
Andrea De Lerma Barbaro,
Roberto S. Accolla,
Douglas M. Noonan
et al.
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33-36
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Differences between familial and sporadic forms of colorectal cancer with DNA microsatellite instability
Summary: Microsatellite instability (MSI) is observed in approximately 13% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inac...
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G. Dionigi,
V. Bianchi,
F. Villa,
F. Rovera,
L. Boni,
M. Annoni,
P. Castano,
R. Dionigi
et al.
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37-42
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Stool test for colorectal cancer screening: What is going on?
Summary: Given the increasing incidence of colorectal cancer (CRC), performing new and cost-effective stool tests is of particular importance for early diagnosis and treatment. In the present review, ...
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Elena Bonanno,
Francesco Rulli,
Gabriele Galatà,
Sabina Pucci,
Fabiola Sesti,
Attilio Maria Farinon,
Luigi Giusto Spagnoli
et al.
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43-45
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Imaging of colorectal cancer: Introduction
Colorectal cancer (CRC) is a common disease and a major cause of cancer-related death in Western countries.
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C. Fugazzola,
S. Iosca
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47-48
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Rectal cancer staging
Summary: Endorectal-US is the most suitable imaging technique in the initial staging of rectal cancer and it is mostly accurate in evaluating early stages and in demonstrating the perirectal spread of...
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Pietro Torricelli
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49-50
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The role of EUS and MRI in rectal cancer staging
Summary: Rectal cancer continues to be one of the most common tumors worldwide. Its prognosis mainly depends on early diagnosis and precise stage evaluation in order to choose the most effective treat...
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F. Rovera,
G. Dionigi,
L. Boni,
S. Cutaia,
M. Diurni,
R. Dionigi
et al.
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51-52
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The surgeon as a prognostic factor in the surgical treatment of rectal cancer
Summary: Over the past 2 decades the surgeon and the hospital where he or she works have been considered to play an important role in the prognosis of the rectal cancer patients. The rate of sphincter...
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Antonio Di Cataldo,
Beniamino Scilletta,
Rosalia Latino,
Aldo Cocuzza,
Giovanni Li Destri
et al.
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53-56
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Preliminary results of laparoscopic colorectal resections: Does surgeon's age influences outcomes?
Summary: Introduction: Several randomized controlled trials demonstrated that laparoscopic colon resection is a safe and effective technique for colon and rectum diseases. In fact mini-invasive proced...
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L. Boni,
M. Di Giuseppe,
C. Bertoglio,
A. Benevento,
G. Dionigi,
F. Rovera,
R. Dionigi
et al.
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57-60
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What happens after the learning curve? A single surgeon's experience of 412 laparoscopic left colectomies and rectal resections
The learning curve in laparoscopic colorectal surgery offers some open issues:
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Franco Caravati,
Fabio Ceriani
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61-63
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Colorectal cancer: The role of laparoscopy
Summary: Since the first report in 1991 the laparoscopic resection of colon cancer is progressing slowly and just in the last 2–3 years is becoming more popular. The resistance to its use by some gene...
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F. Rovera,
G. Dionigi,
L. Boni,
P. Masciocchi,
G. Carcano,
A. Benevento,
M. Diurni,
R. Dionigi
et al.
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65-67
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Radius surgical system and conventional laparoscopic instruments in abdominal surgery: Application, learning curve and ergonomy
Summary: We illustrate our experience with a new class of instruments, the mechanical manipulators (MM), whose main features are an improved mobility, and ergonomy and a modular structure. A specific ...
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N. Di Lorenzo,
I. Camperchioli,
A.L. Gaspari
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69-72
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Oncologic colon cancer resection in emergency: Are we doing enough?
Summary: Background: The primary challenge of surgery for colon cancer (CC) presenting as an emergency is the control of the complication but a proper oncologic technique should not be missed when bow...
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Massimo Chiarugi,
Christian Galatioto,
Sonia Panicucci,
Francesca Scassa,
Giuseppe Zocco,
Massimo Seccia
et al.
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73-77
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The mesenteric and antimesenteric site of the tumor as possible prognostic factor in colorectal cancer: 5-year survival analysis
Summary: Introduction: Colorectal cancer is still one of the many factors of death both in males and in females. To date, the most important prognostic factors are mainly related to the pathological s...
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L. Boni,
F. Cantore,
E. Colombo,
A. Benevento,
G. Dionigi,
F. Rovera,
G. Capriata,
G. Dettori,
R. Dionigi
et al.
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79-82
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Laparoscopic total mesorectal excision after neoadjuvant chemoradiotherapy
Summary: Background: Although several authors have demonstrated that laparoscopic total mesorectal excision (TME) is feasible, safe, and has short-term benefits over open surgery, evidence about oncol...
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Riccardo Rosati,
Stefano Bona,
Uberto Fumagalli Romario,
Ugo Elmore,
Niccolò Furlan
et al.
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83-89
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Surgical treatment of rectal cancer after neoadjuvant chemoradiation. Where are we going?
Summary: Anterior resection of the rectum and abdominoperineal resection with total mesorectal excision represent the standard surgical approach after preoperative chemoradiation in rectal cancer. Man...
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M. Caricato,
F. Ausania,
R. Coppola
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91-92
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The role of adjuvant chemotherapy in colon cancer
Summary: Surgical resection of the primary and regional lymph nodes is still, at this time, the standard treatment of colon cancer. However, the risk of recurrence is still high in many patients. Effo...
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R. Labianca,
L. Milesi,
S. Mosconi,
M.A. Pessi,
G.D. Beretta,
A. Quadri
et al.
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93-96
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Laparoscopic rectal resection with intraoperative radiotherapy in locally advanced cancer: Preliminary results
Summary: Carcinoma of the rectum is a common malignancy, especially in developed countries. The main stay of the therapy for rectal cancer is radical surgery. Total mesorectal excision has emerged as ...
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Ignazio Massimo Civello,
Giuseppe Brisinda,
Francesco Brandara,
Gaia Marniga,
Pasquale Mazzeo,
Francesco Giacchi,
Serafino Vanella
et al.
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97-100
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The role of local excision in rectal cancer after complete response to neoadjuvant treatment
Summary: Correlation between pathological response of primary tumour and mesorectal lymph node involvement was prospectively evaluated to assess the role of local excision (LE) in rectal cancer after ...
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C. Coco,
A. Manno,
C. Mattana,
A. Verbo,
G. Rizzo,
V. Valentini,
M.A. Gambacorta,
F.M. Vecchio,
D. D’Ugo
et al.
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101-104
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Protective stoma in anterior resection of the rectum: When, how and why?
Summary: Background: The use of protective stoma in anterior resection (AR) is controversial. Neoadjuvant therapy, TME and laparoscopy seem to increase the rate of anastomotic dehiscences (a.d.). Pati...
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Giuseppe Pappalardo,
Domenico Spoletini,
Delia Proposito,
Fabio Giorgiano,
Anna Maria Conte,
Fabrizio Maria Frattaroli
et al.
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105-108
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Antibiotic prophylaxis and preoperative colorectal cleansing: Are they useful?
Summary: The utility of antibiotic prophylaxis for colorectal surgery has been assessed and largely confirmed worldwide. There is homogeneous consensus that the antibiotic chosen for prophylaxis must ...
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F. Rovera,
G. Dionigi,
L. Boni,
M.G. Alberio,
A. Coglitore,
G. Carcano,
M. Diurni,
R. Dionigi
et al.
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109-111
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Total mesorectal excision (TME) with laparoscopic approach: 226 consecutive cases
Summary: Background: Total mesorectal excision (TME) of the rectum has been advocated as the gold surgical treatment of the middle and low third rectal cancer. Laparoscopy has gained acceptance among ...
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Carlo Staudacher,
Saverio Di Palo,
Andrea Tamburini,
Andrea Vignali,
Elena Orsenigo
et al.
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113-116
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Laparoscopic intersphincteric resection for low rectal cancer
Summary: The goal of this review is to outline some of the important surgical issues surrounding the management of patients with low rectal cancer submitted to laparoscopic intersphincteric resection ...
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Elena Orsenigo,
Saverio Di Palo,
Andrea Vignali,
Carlo Staudacher
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117-120
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Infectious complications in colorectal surgery
Summary: Postoperative infectious complications still represent a relevant problem in colorectal surgery. They always results in suffering for the patients and often prolonged hospitalization. Further...
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F. Rovera,
G. Dionigi,
L. Boni,
C. Piscopo,
P. Masciocchi,
M.G. Alberio,
G. Carcano,
M. Diurni,
R. Dionigi
et al.
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121-124
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State of the art and recent advance in the treatment of resectable nonmetastatic rectal cancer
Summary: Introduction: Standard treatment is achieving good local control for rectal cancer. Innovative approach is aiming at increasing conservative treatment. Methodology: Strong evidence relies on ...
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C. Ortholan,
J.P. Gerard,
K. Benezery,
E. Francois
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125-128
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The application of sentinel lymph node mapping in colon cancer
Summary: Lymph node status is the most important prognostic factor for colorectal carcinoma. Complete lymph node dissection has historically been an integral part of the surgical treatment of these di...
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G. Dionigi,
P. Castano,
F. Rovera,
L. Boni,
M. Annoni,
F. Villa,
V. Bianchi,
G. Carrafiello,
A. Bacuzzi,
R. Dionigi
et al.
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129-132
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Selecting the optimum treatment for colorectal liver metastases
Summary: There has been much improvement in the management of patients with colorectal liver metastases over the last 20 years. Appropriate selection of both treatment and patients can result in enhan...
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Irving Taylor
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133-136
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Cryosurgical ablation of hepatic colorectal metastases
Summary: Hepatic resection is the treatment of choice for primary and secondary hepatic tumors but only 15–25% of patients with hepatic colorectal metastases are eligible for a curative hepatic resect...
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Alessandro M. Paganini,
Adriana Rotundo,
Luciana Barchetti,
Emanuele Lezoche
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137-140
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Pulmonary resections of single metastases from colorectal cancer
Summary: Background: Surgical resection is the treatment of choice of pulmonary metastases from colorectal cancer. We retrospectively reviewed our experience of pulmonary resections of single metastas...
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N. Rotolo,
L. De Monte,
A. Imperatori,
L. Dominioni
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141-144
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Treatment of peritoneal carcinomatosis from colorectal cancer with cytoreductive surgery and perioperative intraperitoneal chemotherapy: State of the art and future prospects
Summary: Peritoneal carcinomatosis (PC), a malignancy limited to the peritoneal surface, has a severe prognosis, but a new therapeutic approach has resulted in cure in some cases. The treatment consis...
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Isidoro Di Carlo,
Elia Pulvirenti,
Francesca Sparatore,
Adriana Toro,
Stefano Cordio
et al.
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145-148
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Peritoneal carcinomatosis from colorectal cancer: HIPEC?
Summary: Peritoneal carcinomatosis (PC) is a frequent terminal evolution from colorectal cancer. At the time of diagnosis of colon malignancies, PC affects approximately 10% of the patients . Medical ...
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G. Confuorto,
M.E. Giuliano,
A. Grimaldi,
C. Viviano
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149-152
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Colonic stenting for malignant disease: Review of literature
Summary: Colonic stents potentially offer effective palliation for patients with bowel obstruction attributable to incurable malignancy, and a “bridge to surgery” for those in whom emergency surgery w...
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G. Dionigi,
F. Villa,
F. Rovera,
L. Boni,
G. Carrafiello,
M. Annoni,
P. Castano,
V. Bianchi,
M. Mangini,
C. Recaldini,
D. Laganà,
A. Bacuzzi,
R. Dionigi
et al.
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153-155
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Laparoscopic colorectal resections with transvaginal specimen extraction for severe endometriosis
Summary: Introduction: Bowel resection is now considered the “gold standard” treatment for severe endometriosis infiltrating the bowel. Laparoscopic colorectal resection can be considered a safe optio...
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L. Boni,
S. Tenconi,
P. Beretta,
A. Cromi,
G. Dionigi,
F. Rovera,
R. Dionigi,
F. Ghezzi
et al.
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157-160
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Intestinal obstruction secondary to endometriosis: A rare case of synchronous bowel localization
Summary: Although endometriosis is a common disease in women of childbearing age, intestinal endometriosis is unusual and may cause clinically significant complications. We report a 35-year-old woman ...
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G. Preziosi,
M. Cristaldi,
L. Angelini
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161-163
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Management of simultaneous abdominal aortic aneurysm and colorectal cancer: The rationale of mini-invasive approach
Summary: The concomitant occurrence of abdominal aortic aneurysm and malignancy represents a therapeutic dilemma. Both lesions should be treated to achieve best life expectancy; the main controversy r...
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Nicola Rivolta,
Gabriele Piffaretti,
Matteo Tozzi,
Chiara Lomazzi,
Francesca Riva,
Alessia Alunno,
Luigi Boni,
Patrizio Castelli
et al.
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165-167
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Primary colorectal lymphomas: Review of the literature
Summary: Primary colorectal lymphoma is an infrequent disease of unknown origin and with a growing incidence. Primary colorectal lymphoma accounts for only about 0.2% of large intestinal malignancies....
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G. Dionigi,
M. Annoni,
F. Rovera,
L. Boni,
F. Villa,
P. Castano,
V. Bianchi,
R. Dionigi
et al.
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169-171
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Stapled hemorroidopexy: Day surgery or one day surgery?
Summary: Hemorrhoidal disease is one of the most common anorectal disorders, from 10% to 20% of all patients admitted at a clinical investigation need to undergo surgery, stapled haemorrhoidopexy is g...
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D.P. Greco,
G. Miotti,
A. Della Volpe,
C. Magistro,
S. De Carli,
R. Pugliese
et al.
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173-175
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The impact of perioperative blood transfusion on clinical outcomes in colorectal surgery
Summary: Colorectal cancer is the second-leading cause of cancer-related death in the US. The prognosis of advanced colorectal cancer remains poor in spite of the advances obtained in recent years wit...
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G. Dionigi,
F. Rovera,
L. Boni,
G. Carrafiello,
C. Recaldini,
M. Mangini,
D. Laganà,
A. Bacuzzi,
R. Dionigi
et al.
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177-182
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