Surgical Oncology
Volume 18, Issue 4 , Pages 366-378, December 2009

Gene expression profiling: Decoding breast cancer

  • Femke de Snoo

      Affiliations

    • Department of Medical Affairs, Agendia BV, Science Park 406, Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 20 462 1561; fax: +31 20 462 1505.
    • ,
  • Richard Bender

      Affiliations

    • Department of Medical Affairs, Agendia Inc, Huntington Beach, CA, USA
    • ,
  • Annuska Glas

      Affiliations

    • Department of Research and Development, Agendia BV, Science Park 406, Amsterdam, The Netherlands
    • ,
  • Emiel Rutgers

      Affiliations

    • Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Accepted 24 July 2009.

Abstract 

Gene expression assays that are used in daily clinical practice for treating early breast cancer patients have been introduced in the clinic only recently. This review discusses the development of these arrays, summarizes the validation of those that are commercially available and indicates how the information provided by these assays can help in the care of patients. The review also provides an extensive overview of commercially available assays focusing on MammaPrint, the first and only assay for breast cancer management that has been cleared by the FDA.

Keywords: Breast cancer, Gene expression, Prognosis, Prediction, Multigene assay, Personalized medicine, Genetic profile, Therapy response

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PII: S0960-7404(09)00080-2

doi:10.1016/j.suronc.2009.07.005

Surgical Oncology
Volume 18, Issue 4 , Pages 366-378, December 2009

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