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Surgical Oncology
Volume 19, Issue 1
, Pages e11-e21
, March 2010
Herceptin and breast cancer: An overview for surgeons
References
- . The HER receptor family: a rich target for therapeutic development. Int J Radiat Oncol Biol Phys. 2004;58:932–940
- . The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat Res. 2000;103:57–75
- . Biological rationale for HER2/neu (cerbB2) as a target for mono clonal antibody therapy. Semin Oncol. 2000;27(Suppl. 9):13–19
- . Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235(4785):177–182
- . Biology of HER2 and its importance in breast cancer. Oncology. 2001;61(Suppl. 2):1–13
- . Trastuzumab as adjuvant therapy for early breast cancer: the importance of accurate human epidermal growth factor receptor 2 testing. Arch Pathol Lab Med. 2008 Jun;132(6):1008–1015
- . HER2+ breast cancer: review of biologic relevance and optimal use of diagnostic tools. Am J Clin Pathol. 2008 Feb;129(2):263–273
- . Angiogenesis and c-erbB-2 (HER2/neu) overexpression status in primary breast cancer patients: an analysis of 158 needle core biopsies. Rom J Morphol Embryol. 2007;48(2):121–129
- Monoclonal antibody therapy of human cancer: taking the HER2 protooncogene to the clinic. J Clin Immunol. 1991;11(3):117–127
- . HER2-positive breast cancer: current treatment strategies. Cancer Invest. 2008 Jul;26(6):545–552
- Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA. 1992;89:4285–4289
- . Trastuzumab – mechanism of action and use in clinical practice. N Engl J Med. 2007 Jul 5;357(1):39–51
- Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism?. Br J Cancer. 2006;94:259–267
- . Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med. 2000;6:443–446
- . Natural killer cell cytotoxicity of breast cancer targets is enhanced by two distinct mechanisms of antibody-dependent cellular cytotoxicity against LFA-3 and HER2/neu. Exp Hematol. 1999;27:1533–1541
- . Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature. 2002;416:279–280
- . Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling. Ann Oncol. 2001;12:21–22
- The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. J Biol Chem. 2003;278:23 441–23 450
- Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies. Cancer Immunol Immunother. 1993;37:255–263
- Trastuzumab-mediated antibodydependent cellular cytotoxicity against esophageal squamous cell carcinoma. Clin Cancer Res. 2005;11:4898–4904
- . Trastuzumab (herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells. Cancer Res. 2001;61:4744–4749
- . Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res. 1999;59:1347–1355
- . Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res. 2002;62:4132–4141
- . Adjuvant trastuzumab: a milestone in the treatment of HER-2-positive early breast cancer. Oncologist. 2006;11(Suppl. 1):4–12
- . Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4. Adv Exp Med Biol. 2003;532:253–268
- . Trastuzumab and antiestrogen therapy: focus on mechanisms of action and resistance. Am J Clin Oncol. 2006 Feb;29(1):90–95
- Neo-adjuvant trastuzumab induces apoptosis in primary breast cancers. J Clin Oncol. 2005 Apr 10;23(11):2460–2468
- . Herceptin sensitizes ErbB2 overexpressing cells to apoptosis by reducing antiapoptotic Mcl-1 expression. Clin Cancer Res. 2006;12(3 Pt 1):845–853
- . Human epidermal growth factor receptor 2 regulates angiopoietin-2 expression in breast cancer via AKT and mitogen-activated protein kinase pathways. Cancer Res. 2007;67(4):1487–1493
- HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene. 2006;25:6986–6996
- . Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol. 2007 Jun;18(6):977–984
- . Trastuzumab: triumphs and tribulations. Oncogene. 2007 May 28;26(25):3637–3643
- . HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res. 2006;8(6):215
- Use of chemotherapy plus a monoclonal anti body against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344(11):783–792
- Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol. 2005;23(19):4265–4274
- . N98-32-52: efficacy and tolerability of two schedules of paclitaxel, carboplatin and trastuzumab in women with HER2 positive metastatic breast cancer: an NCCTG randomized phase II trial. [abstr 216] Breast Cancer Res Treat. 2003;82:S47
- . Effects on quality of life of combined trastuzu mab and chemotherapy in women with metastatic breast cancer. J Clin Oncol. 2002;20(14):3106–3113
- Herceptin prescribing information. Available from: www.gene.com2006;[accessed 1.10.07]
- National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: breast cancer. Available from: www.nccn.org/professionals/physician_gls/PDF/breast.pdf. [accessed 1.10.07].
- Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE, et al. Docetaxel and cyclophosphamide followed by paclitaxel with or without trastuzumab as adjuvant therapy for patients with HER2- positive operative breast cancer. Combined analysis of NSABP-B-31 and NCCTGN9831. Program and abstracts of the 41st annual meeting of the American Society of Clinical Oncology, Orlando, Florida, May 13–17, 2005, Oral presentation during symposium, advances in monoclonal antibody therapy for breast cancer.
- Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353:1673–1684
- . Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer. J Clin Oncol. 2007;25(Suppl. 18):512
- . Phase III trial comparing AC-T with AC-TH and with TCH in the adjuvant treatment of HER2-positive early breast cancer patients: second interim efficacy analysis. Breast Cancer Res Treat. 2006;100(Suppl. 1):53
- Piccart-Gebhart MJ, The Breast International Group. Advances in monoclonal antibody therapy for breast cancer. HERA trial. Program and abstracts of the 41st annual meeting of the American Society of Clinical Oncology, Orlando, Florida, May 13–17, 2005.
- 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet. 2007;369:29–36
- Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med. 2006;354:809–820
- . Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials. BMC Cancer. 2007 Aug 8;7:153
- Benefit of taxanes as adjuvant chemotherapy for early breast cancer: pooled analysis of 15,500 patients. Cancer. 2006;106(11):2337–2344
- . Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study. J Clin Oncol. 2003;21(1):46–53
- . Preoperative trastuzumab and vinorelbine is highly active, well-tolerated regimen for HER2 3+/FISH
+
stage II/III breast cancer. [abstr 86] Proc Am Soc Clin Oncol. 2003;22:[abstract no. 86] - . Neo-adjuvant herceptin/taxotere/cisplatin in the treat ment of locally advanced and inflammatory breast cancer. [abstr 196] Proc Am Soc Clin Oncol. 2002;21:[abstract no. 196]
- Neo-adjuvant trastuzumab and docetaxel in breast cancer: preliminary results. Clin Breast Cancer. 2003;4:348–353
- Dose-dense neo-adjuvant treatment of women with breast cancer utilizing docetaxel, vinorelbine and trastuzumab with growth factor support. Breast Cancer Res Treat. 2003;82:S55
- Carey LA, Dees EC, Sawyer L. Response to trastuzumab given with paclitaxel immediately following 4AC as initial therapy for primary breast cancer. Proceedings of the 24th San Antonio breast cancer symposium; 2002.
- Significantly higher pathologic complete remission rate after neo-adjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2- positive operable breast cancer. J Clin Oncol. 2005;23(16):3676–3685
- Neo-adjuvant trastuzumab in locally advanced breast cancer (NOAH): antitumor and safety analysis. J Clin Oncol. 2007;25:18S;[abstract 532]
- . Integrating trastuzumab in the neo-adjuvant treatment of primary breast cancer: accumulating evidence of efficacy, synergy and safety. Crit Rev Oncol Hematol. 2008 Apr;66(1):31–41
- Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression. J Clin Oncol. 2004;22(6):1063–1070
- Capecitabine vs. capecitabine
+
trastuzumab in patients with HER2-positive metastatic breast cancer progressing during trastuzumab treatment: The TBP phase III study (GBG 26/BIG 3–05). J Clin Oncol. 2008;26(May 20 Suppl.):[abstr 1025] - Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol. 2002;20(5):1215–1221
- . TLC D99 (D, Myocet) and Herceptin (H) is safe in advanced breast cancer (ABC): final cardiac safety and efficacy analysis. Proc Am Soc Clin Oncol. 2002;21:55a
- Reversibility of trastuzumab related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol. 2005;23(31):7820–7826
- . Type II chemotherapy-related cardiac dysfunction: time to recognize a new entity. J Clin Oncol. 2005;23:2900–2902
- Herceptin (Trastuzumab) package insert, HER2 package insert. Genetech, Inc., USFDA; January 2000;
- Perez EA, Suman VJ, Davidson NE, Kaufman PA, Martino S, Dakhil SR, et al. Exploratory analysis from NCCTG N9831: do clinical and laboratory characteristics predict cardiac toxicity of trastuzumab when administered as a component of adjuvant therapy? Program and abstracts of the 28th annual San Antonio breast cancer symposium, San Antonio, Texas; 2005 [abstr 2038].
- Trastuzumab associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol. 2007 Jul 23;25:3859–3865
- Cardiotoxicity and incidence of brain metastases after adjuvant trastuzumab for early breast cancer: the dark side of the moon? A meta-analysis of the randomized trials. Breast Cancer Res Treat. 2008 May;109(2):231–239[Epub 2007 Jul 19]
- . Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/cyclophosphamide (AC)_paclitaxel (T) vs. AC_T with trastuzumab (H). J Clin Oncol. 2007;25(Suppl. 18):513
- Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol. 2005;23:7811–7819
- Update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/cyclophosphamide (AC) paclitaxel (T) vs. ACT with trastuzumab (H). J Clin Oncol. 2006;24(Suppl. 18):581
- Effect of cardiac dysfunction on treatment out comes in women receiving trastuzumab for HER2-overexpressing metastatic breast cancer. Clin Breast Cancer. 2004;5(4):293–298
- . Trastuzumab-associated cardiotoxicity. Cancer. 2002;95:1592–1600[Erratum, Cancer 2003;97:1136.]
- 2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2001;19(6):1865–1878
- . Current issues in ER and HER2 testing by IHC in breast cancer. Mod Pathol. 2008 May;21(Suppl. 2):S8–S15
- Laboratory assessment of the status of Her-2/neu protein and oncogene in breast cancer specimens: comparison of immunohistochemistry assay with fluorescence in situ hybridisation assays. J Clin Pathol. 2000;53:374–381
- Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry. J Clin Oncol. 2000;18:3651–3664
- . Improved survival benefit from herceptin (trastuzumab) in patients selected by fluorescence in situ hybridization (FISH). Proc Am Soc Clin Oncol. 2001;20:22a;[abstract]
- . Comparison of fluorescence in situ hybridization and immunohistochemistry for the evaluation of HER-2/neu in breast cancer. J Clin Oncol. 1999;17(7):1974–1982
- Real-world performance of HER2 testing—national surgical adjuvant breast and bowel project experience. Natl Cancer Inst. 2002;94(11):852–854
- HER2 testing by local, central, and reference laboratories in the NCCTG N9831 Intergroup Adjuvant Trial. J Clin Oncol. 2006;24:3032–3038
- American Society of Clinical Oncology/College of American Pathologists Guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med. 2007;131:18
- American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol. 2007;25:118–145
- . Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;365(9472):1687–1717
- . CALGB 150002: correlation of HER2 and chromosome 17 (ch17) copy number with trastuzumab (T) efficacy in CALGB 9840, paclitaxel (P) with or without T in HER2_ and HER2- metastatic breast cancer (MBC). J Clin Oncol. 2007;25(Suppl. 18):1009
- . HER2 status and benefit from adjuvant trastuzumab in breast cancer. N Engl J Med. 2008 Mar 27;358(13):1409–1411
- Benefit from adjuvant trastuzumab may not be confined to patients with IHC 3+ and/or FISH-positive tumors: central testing results from NSABP B-31. J Clin Oncol. 2007;25:18S;[Abstr 511]
- . The complexity of genotypic alterations underlying HER2-positive breast cancer: an explanation for its clinical heterogeneity. Curr Opin Oncol. 2007 Nov;19(6):552–557
- Topoisomerase II-alpha gene amplification as a predictor of responsiveness to anthracyline-containing chemotherapy in the Cancer International Research Group 006 clinical trial of trastuzumab (herceptin) in the adjuvant setting. [abstract no. 1045] Breast Cancer Res Treat. 2005;94(Suppl. 1):S54
- Trastuzumab sensitivity of breast cancer with coamplification of HER2 and cMYC suggests proapoptotic function of dysregulated cMYC in vivo. Cancer Cell. 2004;5(4):317–328
- erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer. J Natl Cancer Inst. 1998;90:1361
- Amplification and deletion of topoisomerase I alpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am J Pathol. 2000;156(3):839–847
- . Trastuzumab: is the new evidence revolutionary?. J Cancer Res Ther. 2006 Jul-Sep;2(3):144–146
- Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomized trials. Early Breast Cancer Trialists' Collaborative Group. Lancet. 2000;355:1757–1770
- Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: overview of the randomized trials. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Lancet. 2006;366:2087–2106
- Cause specific mortality in long term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol. 1994;12:447–453
- Halyard MY, Pisansky TM, Solin LJ, Marks LB, Pierce LJ, Dueck A, et al. Adjuvant radiotherapy (RT) and trastuzumab in stage I-IIA breast cancer: toxicity data from North Central Cancer Treatment Group Phase III trial N9831, 24; 2006, p. 523.
- Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer. 2003;97:2972–2977
- Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer. 2004;91:639–643
- . CNS metastases in breast cancer. J Clin Oncol. 2004;22:3608–3617
- . Traztuzumab in CSF. J Clin Oncol. 2000;18:2350–2351
- . HER2 targeted therapy in breast cancer beyond herceptin. Rev Endocr Metab Disord. 2007 Sep;8(3):269–277
PII: S0960-7404(08)00105-9
doi: 10.1016/j.suronc.2008.11.001
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Surgical Oncology
Volume 19, Issue 1
, Pages e11-e21
, March 2010
